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Pirbright Nipah virus.jpg Credit: NIAID.
Colorized transmission electron micrograph of a Nipah Virus particle (green) near the edge of an infected cell (blue). Image captured and color-enhanced at the National Institutes of Allergy & Infectious Diseases Integrated Research Facility in Ft. Detrick, Md.

Nipah vaccines for pigs create ‘impressive’ immune response

Results suggest that modified bovine herpes virus could also be used to make vaccines for other pig diseases like African swine fever virus.

Pirbright Institute researchers in the U.K. have shown that two new potential vaccines against Nipah virus developed by the University of Parma generate a strong immune response in pigs.

According to an announcement from the institute, these results suggest that the vaccines could protect pigs against Nipah virus infection, which can cause respiratory problems and fatal encephalitis in pigs and humans. By preventing the spread of the virus through pig populations, the novel vaccines would also lower the chances of people contracting the disease, Pirbright added.

Nipah virus typically infects bats, but pigs can become infected by consuming fruit contaminated with bat secretions. The spread of the virus from pigs to people was responsible for the first and most severe human Nipah outbreak in Malaysia during 1998-99, when almost 200 pig farmers died after contracting the virus from infected pigs.

Pirbright noted that eradicating the Nipah virus from pigs in Malaysia was dangerous and costly, requiring the army to cull almost half of the national herd and costing an estimated $582 million.

In the new study, published in Vaccines, the team reported that the two vaccine candidates generated strong antibody and cellular immune responses in pigs. Since it is thought that both types of immune response are important for protection against Nipah virus, these results provide a solid basis for their further investigation in vaccine development for use in pigs and potentially other species, Pirbright said.

To create the vaccines, scientists genetically engineered bovine herpes viruses (BoHV-4) to deliver Nipah virus proteins to pigs. The team selected the G and F proteins that Nipah virus is known to use to enter cells and facilitate cell-to-cell spread. When presented to the immune system, these proteins trigger a response that prepares the host to fight the infection.

“We were impressed by the magnitude of the immune responses stimulated by the BoHV-4 vaccines, especially the T cell responses. Our results suggest that BoHV-4 could also be used to make vaccines for other pig diseases where T cell responses are thought to play an important role in protection, such as African swine fever virus. This shows great potential for the future of this vaccine delivery system,” said professor Simon Graham, head of the Porcine Reproductive & Respiratory Syndrome Immunology Group at Pirbright.

Now that the team has shown that the vaccine candidates induce potent immune responses, the next step is to assess whether this will protect pigs when they are infected with the Nipah virus after receiving the vaccine, the institute added. A complementary diagnostic test will also be developed that can differentiate between infected and vaccinated animals, which would enable vaccines to be stockpiled and then utilized during outbreaks.

Furthermore, Pirbright said as emerging viruses continue to create new outbreaks around the world, preventing and controlling viral diseases that can spread from animals to people (known as zoonoses) has become a global priority. Protecting pigs from diseases such as Nipah can improve animal welfare, safeguard national economies and prevent "spillover" infection to people.

TAGS: Swine
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