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N&H TOPLINE: Nitrogen identified as key driver for gut healthN&H TOPLINE: Nitrogen identified as key driver for gut health

Scientists one step closer to understanding link between different diet strategies and gut health. Also: Algal feed ingredients approved for livestock in Canada.

Tim Lundeen 1

December 23, 2016

3 Min Read
N&H TOPLINE: Nitrogen identified as key driver for gut health

Scientists are one step closer to understanding the link between different diet strategies and gut health, with new research presenting the first general principles for how diet affects the microbiota.

Researchers from the University of Sydney in Australia have found that the availability of intestinal nitrogen to microbes in the gut plays a key role in regulating interactions between gut microbes and their host animal. The study is published recently in Cell Metabolism and was led by researchers at the University of Sydney's Charles Perkins Centre.

"There are many different diet strategies that claim to promote gut health, and until now, it has been very difficult to establish clear causality between various types of diet and their effect on the host's microbiome. This is because there are many complex factors at play, including food composition, eating pattern and genetic background," said lead author associate professor Andrew Holmes from the Charles Perkins Centre and School of Life & Environmental Sciences.

"This research really lays the groundwork for future modelling by setting out the rules for a general model of how diet shapes the gut ecosystem. The simple explanation is that when we eat in a way that encourages cooperation between ourselves and bacteria, we achieve a good microbiome, but when we eat in a way that doesn't require cooperation, this lets bacteria do whatever they want — and mischief can ensue."

According to the researchers, the balance of gut bacteria in the microbiome plays a key role in such functions as immune regulation and digestive well-being and has been linked to other health outcomes like obesity. Past studies have identified several patterns for how diet influences the microbiome, yet this has not led to a workable model that explains microbial response across many different types of diets.

This new research is the latest in a series stemming from a seminal study in which 25 different diets comprised of different amounts of protein, carbohydrates and fat were systematically varied in 858 mice.

Despite the huge diversity of gut bacteria, two main response patterns emerged in the study:  microbe species either increased or decreased in their abundance, depending on the animal’s protein and carbohydrate intake.

"The largest nutrient requirements for our gut bacteria are carbon and nitrogen in the foods we eat. As carbohydrates contain no nitrogen but protein does, the bacterial community response to the host animal’s diet is strongly affected by this diets' protein-carbohydrate ratio," Holmes said. "The fact that this same pattern was seen across almost all groups of gut bacteria indicates that the makeup of the microbial ecosystem is fundamentally shaped by a need to access nitrogen in the intestinal environment."

The researchers' new model suggests that while high-carbohydrate diets were the most likely to support positive interactions in the microbiome, such benefits were relative to the protein intake of the host animal.

Researchers hope the new findings will lay the foundations for more accurate computer simulations to test hundreds of different diet variants, thus helping better predict which dietary combinations lead to optimal gut health.


CFIA-approved algae product will enable producers to bring DHA-enriched pork, milk and eggs to market

Alltech announced that its algae nutritional products are now registered with the Canadian Food Inspection Agency (CFIA) for use in the diets of pigs, dairy cows and laying hens in Canada.

According to the company, algae contains docosahexaenoic acid (DHA), an omega-3 fatty acid naturally found in some species of algae and in fatty fish used for fish oil, that can naturally enrich pork, milk and eggs.

“Consumers are becoming increasingly nutrition focused, seeking out foods that provide specific health benefits when shopping at the supermarket,” said Nikki Putnam, registered dietitian nutritionist at Alltech.

Algae are gaining attention for their application to the feed and food industries as a highly sustainable source of DHA, the company said.

Research has demonstrated DHA’s importance as an essential nutrient for health at all stages of both human and animal life. In people, DHA is essential for brain and eye development.

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