Antibiotics used to treat bacterial infections can contribute to antimicrobial resistance (AMR) that spreads amongst human, animal, and plant populations, weakening our ability to prevent and treat future infections. To effectively tackle AMR and reduce its impact on global health security, the USAID-funded Transformational Farm Output Risk Mitigation (TRANSFORM) project is leveraging multi-sectorial interventions using the One Health approach that recognizes the interdependencies between the health of humans, animals, and the environment. As part of TRANSFORM, the International Poultry Council (IPC) is driving global change within animal agriculture by uniting poultry industry associations and private sector organizations to support antimicrobial use stewardship principles that guide actions to avoid the need to use, but when needed, ensure proper use of antimicrobials.  Joining us with more details are Dennis Erpelding, TRANSFORM - IPC Project Lead; Annie Kneedler, TRANSFORM Chief of Party, and Nicolo Cinotti, IPC Secretary General.