Merck Animal Health introduces Once PMH IN

Only intranasal vaccine to deliver dual bacterial pneumonia protection in cattle.

Merck Animal Health introduced Once PMH IN, the only intranasal vaccine to deliver dual bacterial pneumonia protection in healthy beef and dairy cattle, including calves as young as one week of age. Once PMH IN aids in the control of respiratory disease caused by Mannheimia haemolytica and in the prevention of disease caused by Pasteurella multocida — the leading causes of early-onset bovine respiratory disease (BRD).

"The intranasal administration of Once PMH IN stimulates a strong immune response because vaccine antigens are delivered directly to mucosal surfaces in the nose — the major sites of immune response in cattle," said Dr. Rick Sibbel, Merck Animal Health director of beef cattle technical services.

Studies demonstrate young calves given an intranasal administration of Once PMH IN performed better on body temperature and weight gain measures compared to calves given a commercial subcutaneous pasteurella vaccine.

Once PMH IN is a non-adjuvanted formulation with two dosing options — 1 mL applied in each nostril of the animal or a 2-mL dose delivered in one nostril.

While annual revaccination is recommended, the vaccine can be administered more frequently, depending on the farm's risk assessment or if the herd faces epidemic conditions, the announcement said.

Once PMH IN is available in 10-dose and 50-dose packages. To further assist in vaccine delivery, Merck Animal Health has developed new, less invasive cannula and pump-its, which are available through Merck Animal Health representatives or veterinarians.

To learn more about Once PMH® IN, visit

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