Global flu viral diversity assessed

Global flu viral diversity assessed

Scientists are looking to better understand and monitor diversity of avian flu viruses.

A GROUP of international scientists completed the first global inventory of influenza strains in birds by reviewing more than 50 published studies and genetic data, providing new insight into the drivers of viral diversity and the emergence of diseases that can ultimately affect human health and livelihoods.

The research, published in the journal PLOS ONE and performed as part of the U.S. Agency for International Development's PREDICT project, identified more than 116 avian flu strains in wild birds, which is roughly twice the number found in domesticated birds and more than 10 times the number found in people, according to an announcement from the Wildlife Conservation Society (WCS).

Additionally, an analysis of studies that sampled more than 5,000 birds suggested that some regions may have more viral diversity than others.

Avian flu outbreaks come with no warning. In 2013, an H7N9 avian flu strain caused a deadly outbreak in people in China, WCS said, noting that this surprised virologists because H7N9 had never before caused disease in humans. To date, there have been more than 300 clinical cases of H7N9, with a 33% mortality rate.

This year, another strain known to infect birds, H10N8, also has caused human cases for the first time.

As was the case in the H7N9 outbreak, most direct bird-to-human spillover events — when a virus jumps from one species to another — of avian flu can be traced back to human contact with domesticated poultry, the announcement said. Although avian flu strain diversity often originates in wild birds, it is the mixing of viruses among poultry, pigs and people that substantially heightens the disease risk in humans.

In an effort to improve preparedness, scientists are looking to better understand and monitor the diversity of all avian flu viruses — not just those known to cause disease. Completing the first global inventory of flu strains in birds is a key step in building that understanding.

"This snapshot of the world of flu virus diversity in birds is the outcome of many years of ecology and evolution, as viewed through the lens of surveillance methods utilized by scientists from around the world," said study lead Dr. Sarah Olson, WCS associate director of wildlife epidemiology.

Understanding the natural diversity of viruses is critically important to identifying health risks. However, authorities face a challenge both in focusing efforts in the right places and adequately financing surveillance to describe global flu diversity.

To address this, the authors introduced a new method that borrows approaches used by ecologists to estimate the diversity of flu viruses in a particular location. With this approach, health authorities can design surveillance programs to detect a given percentage of flu virus diversity, WCS said.

The scientists also looked at patterns of flu diversity in different bird hosts. Mallards carry the highest number of strains at 89, and ruddy turnstones were second with 45. The more a strain was shared across wild bird types, the more likely it was to be found in domesticated birds — a risk factor for spillover events, WCS said.

They also noted that some strains could be specific to certain bird types. For example, gulls and shorebirds (Charadriiformes) carried 10 strains that have not been identified in any other bird order.

According to Olson, "This inventory isn't about blaming wild birds, but it allows us to map what we know and informs our understanding of what drives viral diversity and the emergence of rare viral strains that can infect people. Given that flu viruses can jump from domestic poultry to people, ongoing efforts at improving biosecurity at poultry farms and markets remain key to outbreak prevention."

The study can be found at

Volume:86 Issue:11

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