A research grant from the U.S. Department of Agriculture for nearly $1.2 million is supporting work at Kansas State University toward combating anaplasmosis, a disease that affects cattle in the U.S. and globally.
Kathryn Reif, assistant professor in the diagnostic medicine and pathobiology department in the Kansas State University College of Veterinary Medicine, said the project focuses on optimizing antimicrobial use to control active infection of the hemoparasitic pathogen, Anaplasma marginale, the causative agent of bovine anaplasmosis.
"Different strains of the pathogen are actively circulating in the U.S.," Reif said. "We are using a combination of A. marginale strains, some of which we recently isolated from Kansas cattle herds, to help determine how strains differ in their susceptibility to tetracycline antimicrobials, specifically chlortetracycline, the most common antimicrobial used to control anaplasmosis. We hope that by looking at three different chlortetracycline treatment protocols for cattle, we can provide practical recommendations for the Food & Drug Administration and, ultimately, for cattle producers toward controlling this disease."
Reif said treatment policies should be based on a firm understanding of how the antimicrobial therapeutic effect can be maximized while minimizing risk of resistance development.
"Cattle producers in Kansas and beyond are concerned that the current FDA-approved anaplasmosis treatment regimens are not sufficiently controlling diseases," Reif said. "Also, there is no fully USDA-approved vaccine for anaplasmosis, and the experimental vaccine, available in some states, does not prevent infection. Efficacy concerns over the current anaplasmosis control measures underscore the need for updated science-based recommendations to help cattle producers manage this disease."
While Reif specializes in vector-borne disease research, her research team at Kansas State University consists of experts in many other disciplines, including molecular biologists, clinical pharmacologists, an antimicrobial resistance specialist, extension agents, livestock veterinarians and experts in the development and delivery of innovative decision support tools, Kansas State pointed out in its announcement.
"With these combined skill sets, our team is uniquely qualified to conduct the proposed program of research," Reif said. "Together, we have the capability to answer these innovative research questions and communicate the outcomes effectively to the scientific community and stakeholders in the livestock industry."