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Monitoring flu strains informs swine health management

Iowa State Veterinary Diagnostic Laboratory’s swine influenza surveillance is ready to monitor new and current flu strains

The veterinarian who leads influenza testing at the Iowa State University Veterinary Diagnostic Laboratory (ISU VDL) said the state-of-the-art monitoring and sequencing efforts at the laboratory should allow pork producers to keep up with both current and new influenza strains among their herds.

Phillip Gauger, associate professor of veterinary diagnostic and production animal medicine who leads influenza testing at the ISU VDL, said the lab routinely tracks influenza A viruses present in pigs.

He added that a newly reported strain among pigs in China likely wouldn’t pose a significantly greater threat to humans compared to strains currently circulating among U.S. pigs, should the new strain appear in the U.S.

“Influenza is one of the primary respiratory diseases in swine, and producers are concerned about the health of their herds and the economic burdens caused by disease,” Gauger said.

Pork producers routinely monitor the specific strains of influenza present among their operations to inform health control measures and decisions on vaccine use, Gauger said. Flu vaccines are used primarily on breeding farms to mitigate clinical disease in the sow farms and to confer maternal immunity to piglets, he said.

The ISU VDL is a Level 1 laboratory in the U.S. Department of Agriculture’s National Animal Health Laboratory Network.

Practicing veterinarians send samples to ISU VDL for sequencing, which allows the veterinarians and pork producers to identify specific influenza strains circulating in their herds. Gauger said there are three subtypes of influenza among U.S. pigs: H1N1, H1N2 and H3N2. He said the lab conducts around 30,000 influenza tests on submitted samples annually and sequences individual strains in more than 1,000 positive tests every year. The lab tracks 16 different genetic flu strains from those three subtypes and posts monitoring data on the lab’s FLUture website.

The publicly available data allow veterinarians, swine producers and researchers to identify trends that help them make better decisions regarding the health of their herds, he noted.

“From the genetic perspective, we have a pretty good handle on what’s out there,” Gauger said. “Through collaborative efforts of practicing veterinarians, pork producers, veterinary diagnostic laboratories and the USDA, the U.S. arguably has one of the most extensive systems for monitoring influenza in domestic pig herds anywhere in the world.”

G4 strain warrants monitoring

In recent weeks, a new influenza variant dubbed G4 EA H1N1 has been discussed following a retrospective report from researchers in China. The variant contains genetic segments similar to the H1N1 strain that caused a pandemic in 2009, but Gauger said the same can be said of other flu strains, and that fact alone isn’t cause for alarm.

Additionally, the variant has not been confirmed in the U.S., and Gauger said the monitoring conducted at facilities like the ISU VDL would detect the variant if it infected pigs in the U.S.

“We feel like it’s not any more of a concern than any other strain that can circulate in swine at this time,” Gauger said. “This particular strain in China doesn’t seem to pose a vastly different threat than strains that we’re already monitoring. It’s something that we’ll watch, and the Iowa State Veterinary Diagnostic Laboratory has the ability to detect this strain if it entered the U.S.”

Gauger noted that influenza strains can undergo reassortment, or the process by which flu strains exchange genetic material. Reassortment and other changes to the genome could allow influenza A virus strains in swine to become infectious among humans, although Gauger said virtually any strain has that potential, and it’s difficult to predict when or if that might occur.

The new strain detected in China should not be a cause for panic for swine producers or consumers, Gauger said, noting that it is still important to stay aware and implement effective influenza monitoring and biosecurity measures on farms, regardless.

Gauger also stressed that influenza is a respiratory virus in swine that affects only the respiratory tract. Accordingly, it doesn’t contaminate meat or threaten the safety of the food supply.

TAGS: Swine
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