Scientists at The Pirbright Institute in the U.K. have demonstrated that production and storage of fat is required for Marek’s disease virus (MDV) replication in chickens.
The research identifies new pathways involved in the development of the disease that can help generate control strategies to reduce virus spread, the institute said in an announcement.
Marek’s disease is a major threat to the poultry industry, with losses relating to the disease estimated to be up to $2 billion worldwide. The virus is highly contagious and causes a condition in which arteries are clogged with fatty substances called plaques, Pirbright explained.
The researchers, whose results were published in the Journal of Virology, identified chemical inhibitors that disrupted two different but connected fat production pathways that significantly reduced virus replication. Although these inhibitors helped the team identify the cellular mechanisms that the virus disrupts during its infection cycle, they would not be suitable for antiviral development due to their side effects and potential transfer to eggs and meat.
Dr. Shahriar Behboudi, head of the avian immunology group at Pirbright, said, “Some viruses exploit host cell machinery to produce components required for their replication and spread. We found that MDV uses the host cells to produce and store fats, contributing to replication of virus and possibly clogging the arteries.”
This study was funded by the U.K.'s Biotechnology & Biological Sciences Research Council.