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Soil characteristics may be related to CWD persistence

University of Illinois deer
Amount of clay in a given soil was a major factor in predicting where CWD was more likely to persist.

Deer infected with chronic wasting disease (CWD) are doomed to a slow and certain death, eventually wasting away as they lose the ability to eat and drink. There is no cure and no vaccine, and the number of infected deer continues to rise every year. However, University of Illinois scientists recently published a new study that could help explain the movement of the disease across the landscape.

“Our biggest goal is to support the management of this non-curable disease in an animal that is an economically important resource for the state of Illinois,” said Michelle Green, research assistant professor in the University of Illinois department of animal sciences and co-author of the study.

CWD is caused by a prion, a sort of mutant protein with an unusual folding pattern that tricks the body’s own proteins into mutating, too. After enough proteins get in on the act, holes begin to form in the brain, causing physiological and behavioral changes. The disease is part of a group known as transmissible spongiform encephalopathies, which includes bovine spongiform encephalopathy and a few other rare diseases.

A key element to managing the disease is reducing exposure to the prion. The disease is primarily passed from deer to deer through direct physical contact, but it can also be passed from mother to fetus or picked up indirectly when a deer comes in contact with the disease agent in the environment, the university said. The new study focuses on the indirect pathway.

“When infected deer urinate, defecate or salivate, they can shed prions. When a susceptible deer comes along and licks, ingests or inhales infected soil, it could pick up a prion, but soil is complex. It’s not clear what soil characteristics are associated with the persistence of chronic wasting disease in deer,” explained Nohra Mateus-Pinilla, veterinary epidemiologist at the Illinois Natural History Survey-Prairie Research Institute and study co-author.

In the study, the team looked at the relationship between soil characteristics and the presence of deer with the disease in five northern Illinois counties where infected deer are prevalent. They focused on seven physical and chemical properties of soil that could affect the ability for a prion to stick around in the environment.

“The goal was to identify which soil characteristics have a greater effect on the persistent presence of chronic wasting disease in the five counties,” said Sheena Dorak, lead author of the study and research associate with the Illinois Natural History Survey.

The first step was to break the five-county area into one-mile square sections that had either a strong history of the disease or not. The researchers laid this grid over a detailed soils map and created a statistical model to predict the likelihood that the disease would stick around based on the soils.

According to the analysis, the amount of clay in a given soil was a major determining factor to predict where the disease was more likely to persist. The data clearly indicated a break point that could be useful in future management schemes: Soils with more than 18% clay were associated with a steep drop in cases of the disease.

“I think what’s groundbreaking about this work is finding this threshold. It’s like a switch,” Green said.

“Clay can tend to immobilize molecules, and we think at these higher concentrations, clay is holding onto the prions so they’re not bioavailable,” Dorak added.

Soil pH was also influential, with more cases of the disease at a pH greater than 6.6. Again, changes in soil pH may relate to how “sticky” the soil environment is for prions. Prions don’t stick as well to the soil above a pH of 6.6 and are free to be picked up by curious deer.

The researchers emphasized that their study is observational and based on data from large Natural Resources Conservation Service databases. As such, they cannot confirm exactly what’s going on with prions in the soil based on their work. They noted, though, that their results are important because they provide a clear starting point for experimental follow-up.

“With these results, we can now look at the entire state and say, for example, there are a lot of infected deer in one area, and not too far away, there are soils that have the right mix of conditions to hold prions persistently should an infected deer contaminate the area,” Green said. “We would recommend a management scheme to keep the infected deer out of such high-risk areas.”

The article, “Clay Content & pH: Soil Characteristic Associations with the Persistent Presence of Chronic Wasting Disease in Northern Illinois,” was published in Scientific Reports.

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