The University of Wisconsin-Madison has hired a new investigator to look into the case of the misplaced protein.
“On average, only about a quarter of the crude protein in a dairy ration goes to milk,” said Sebastian I. Arriola Apelo, who joined the university's dairy science department this summer as an assistant professor. “The rest is excreted, basically, in urine and feces. That has a huge environmental impact. It’s harmful for air quality, it’s harmful for water quality, for environment biodiversity and even for human health. So, farmers are getting more and more pressure from government agencies and from consumers who want more environmentally friendly products.”
Wasted protein also adds financial pressure, he said. The cost of feed — especially the expensive high-protein components — is a big factor in milk producers’ tight profit margins.
“We can add more proteins to the diet and produce more milk to match the genetic potential of the animal, but that is very inefficient,” he said. “We have to formulate better diets where the cow consumes less protein or less nitrogen and still produces the same amount of milk and milk components.”
Arriola Apelo’s appointment fills a void created by the retirement of Louis Armentano, who specialized in ruminant nutrition physiology. Like Armentano, Arriola Apelo is interested in the biochemical processes that govern feed efficiency. He earned his doctorate in dairy science from Virginia Tech and then spent three years conducting research at the University of Wisconsin-Madison School of Medicine & Public Health. The medical research helped him prepare for his dairy work, because the metabolic processes he studies are similar in humans and cows.
“What we study (in our lab) is how nutrients, once they reach the cells in the mammary gland, tell the cell to produce more milk or more milk proteins — how they talk to the cell,” Arriola Apelo explained.
Since this kind of signaling is conserved across mammals, Arriola Apelo can study this phenomenon in the cells of genetically mutated mice. Specifically, he is looking at how the 20 amino acids — the main source of nitrogen in dairy cow rations — contribute to milk protein production.
“We are trying to see how much of each amino acid we need to deliver to the mammary gland and how we are going to deliver them,” he said. “In order to improve nitrogen efficiency, we need to feed less and better, meaning diets with less protein content and a better profile of amino acids. To get to that point, we not only need to know which amino acids are important but also how the cow responds to those amino acids from a quantitative standpoint.
“I’m interested in finding a mathematical function that better represents the effect of amino acids on signaling pathways and on milk protein synthesis so the cow can make the best use of dietary nitrogen, putting more into milk and less in urine and feces,” Arriola Apelo added.
Arriola Apelo’s ability to quantify what happens to nutrients at the cellular level will be extremely useful as dairy nutritionists seek to translate the findings from cell-level research into practical models for feeding dairy cows, Armentano noted.
“We’re trying to find out more about the biological mechanisms that cause relationships between what we feed and how the cow responds, but somehow, we have to tie that back to our whole-animal numerical models. This requires both deductive, component research along with quantitative skills that allow us to integrate this cellular knowledge and then make sure our new models work better than our old ones," Armentano said.
Arriola Apelo’s current research is supported by campus start-up funds and a Hatch grant from the U.S. Department of Agriculture’s National Institute of Food & Agriculture.