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Bovine bacteria-based probiotic shields newborn calves from disease

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Bacteria grown from healthy gut microbes collected from day-old dairy calves.

A probiotic developed at the University of Alberta shows promise in improving the health of dairy calves in the essential first weeks of life. 

Normally, the young animals' undeveloped immune systems leave them susceptible to common ailments like diarrhea, which can stunt growth or even result in death. When fed a cocktail of four strains of beneficial gut bacteria, newborn calves appeared to be more protected against common disease-causing bacteria, with few falling ill. 

"The findings are a step forward in ways to make animal health even better for dairy producers," says researcher Maddison Degenshein.

Her research is the first to test particular bacterial strains derived directly from bovines. It builds the understanding of how probiotics could shield calves from disease until their natural immunity kicks in.

"The building blocks we give them at this vulnerable time could influence future factors like milk production," says Degenshein, who conducted the work for her master's in science in the Faculty of Agricultural, Life and Environmental Sciences.

The bacteria Degenshein worked with were grown from healthy gut microbes collected from day-old dairy calves, so it was native to the animals when it was fed to them as a probiotic in milk supplements. That gave them a homegrown head start, she says.

"We know that this bacteria is what healthy cows already have in their guts. The calves would eventually develop it anyway, but with the probiotic, they'll have it sooner, and it works with their natural physiology," Degenshein says.

Probiotic supplements developed from plant-based bacterial strains — such as the yeast used to make beer and sourdough bread — are commonly used in cattle feed. But a strain native to bovines would be more sustainable, because it's readily available and easily cultivated from the animals' own manure, she notes. 

Besides preventing costly disease and loss of production, cow-derived probiotics could also benefit the dairy industry by being used to enrich early, poor-quality milk produced by the mothers that is usually considered a waste product.

"Knowing it could instead be fed to the calves would keep it from being thrown away," Degenshein notes.

Degenshein's research also helped pinpoint the window of time that calves are most vulnerable to illness: the first six to nine weeks of life. 

"That tells us when their immune systems are starting to function, which allows producers to have more focused care before that time period. And we now know that after nine weeks, the calves will be hardier and more capable of fighting off potential diseases," she says. "It gives more insight into what's going on in early life and it helps support scientists who are considering areas that need more exploration, like immune system research. They can go from there."

Degenshein's work is part of a ruminant nutrition research program headed by professor Anne Laarman in the Department of Agricultural, Food and Nutritional Science, and Degenshein helped develop the probiotic in the lab of animal nutrition researcher Leluo Guan. 

Her findings will be supplemented by analysis in Guan's lab to further measure the effectiveness of the probiotics on calf gut health. 

"If we see more positive results, it could eventually be made available to industry. That would make more probiotics available that are safe and productive for calves," Degenshein says. 

The research was supported by funding to Guan from Alberta Milk and Results Driven Agriculture Research, and by a Natural Sciences and Engineering Research Council of Canada Industrial Research Chair grant awarded to Laarman.

Source: University of Alberta, which is solely responsible for the information provided, and wholly owns the information. Informa Business Media and all its subsidiaries are not responsible for any of the content contained in this information asset.

TAGS: Dairy
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