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Merck AH Nasalgen 3.jpg
Merck Animal Health has launched Nasalgen 3, the newest option for intranasal respiratory vaccination that provides three-way protection against the most common pneumonia-causing viral pathogens.

Merck Animal Health launches Nasalgen 3

Three-way vaccine offers longest duration of immunity against IBR.

Merck Animal Health (known as MSD Animal Health outside the U.S. and Canada) has introduced Nasalgen 3, a three-way intranasal vaccine that protects beef and dairy cattle from the most common pneumonia-causing viral pathogens.

Administering intranasal vaccines to neonatal calves is considered one of the most effective strategies to put protective immunity in place quickly and establish a strong foundation for future respiratory protection, Merck said.

Nasalgen 3 has the longest six-and-a-half-month duration of immunity (DOI) against infectious bovine rhinotracheitis (IBR), an 11-week DOI against bovine respiratory syncytial virus (BRSV) and a three-month DOI against parainfluenza 3 (PI3).

“Nasalgen 3 mimics natural exposure to the most common pneumonia viruses,” said Dr. Scott Nordstrom, associate director of ruminant life cycle management, Merck Animal Health. “The intranasal administration of Nasalgen 3 stimulates a strong, early immune response because the vaccine antigens are delivered to mucosal surfaces in the nose — an area loaded with immunologically active tissues.”

Nasalgen intranasal vaccines avoid interference from maternal antibodies in colostrum that can block injectable vaccines and are less stressful on calves compared to similar injectable vaccinations, the announcement said. Nasalgen 3 also is designed with an IBR that is not temperature-sensitive, so the vaccine will replicate and protect in a moderate to high temperature environment.

“If producers are working cattle in warm temperatures, Nasalgen 3 will still replicate,” Nordstrom said. “The IBR antigen elicits a rapid interferon response as well, which provides non-specific protection against many viruses. Cattle are protected early on and then develop both a serum and mucosal antibody response within two weeks of vaccination.”


Not only is the single 2-mL dose easy to administer, the unique blue shadow dye clearly indicates which animals have been vaccinated. With needle free intranasal administration, carcass quality is not compromised and the product meets best management practices outlined in the industry’s Beef Quality Assurance program, the company said.

Nasalgen 3 is proven safe for use in pregnant cows and in calves nursing pregnant cows, as well as young calves. The vaccine is available in 2-mL, 20-mL and 100-mL packages. Consult a veterinarian for specific usage guidance.

Nasalgen 3 is an extension of the Nasalgen portfolio and is supported by the technical services and customer service network at Merck Animal Health.

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