New hoof disease treatments investigated

New hoof disease treatments investigated

Digital dermatitis control requires innovative, long-term strategies.

FOR almost 40 years, digital dermatitis — also called heel warts — has plagued cattle throughout the world, causing painful hoof lesions that limit the amount of time cows can stand and feed, thus hindering animal welfare and food production.

The disease can be found on almost every beef and dairy farm in North America, so it has a significant economic impact on those industries in the U.S.

Researchers at the University of Wisconsin-Madison School of Veterinary Medicine are helping to find new ways to address the disease. Some of this work has led to the development of safer, more effective treatments. However, the road to these innovative approaches began with the creation of an effective testing method.

"For digital dermatitis, we developed an experimental infection model to reproduce and treat acute digital dermatitis lesions in cattle in a standardized way and in a controlled environment," Dorte Dopfer, University of Wisconsin-Madison assistant professor of food animal medicine and an expert in veterinary epidemiology, said. This involved isolating a very small population of cattle in a laboratory setting free from other factors that can affect the natural course of the disease.

According to Dopfer, the experimental model helps improve animal welfare. Many treatment and preventive measures hit the market before being properly tested, which can be detrimental to millions of cattle. The infection model allows her research team to prescreen products on a small-scale population before they are used in the field.

"In addition, the impact on the test cows is minimal," Dopfer said. "As part of any study, the induced acute lesions are treated with antibiotics immediately. The pain is gone within a day, and the lesions do not become chronic. The cattle lead a perfectly healthy life afterwards."

The experimental model has been used successfully in university/industry partnerships aimed at developing better ways to prevent and treat digital dermatitis.

Zinpro Corp. has been collaborating with Dopfer on clinical trials since 2010. By analyzing data from those trials, she and Arturo Gomez Rivas, a research assistant at the School of Veterinary Medicine, helped assess the effectiveness of treatments that prevent digital dermatitis in pre-calving heifers.

One of these treatments is a new approach to supplementing cattle diets with trace minerals, such as zinc. According to Dopfer, the study showed that treatments with feed ingredients containing these minerals can reduce the prevalence of digital dermatitis. As an added benefit, this cuts down on the need for hoof baths, which involve soaking infected hooves in solutions of copper sulfate, formaldehyde or other chemicals.

Dopfer and her colleagues have also partnered with another company, Laboratoire M2 of Sherbrooke, Que., to evaluate the effects of a safer, alternative hoof bath solution through field trial observations. Laboratory tests have shown that the company's product, which contains botanically derived active ingredients, effectively kills and inhibits treponemes, the main bacteria that cause digital dermatitis.

"The cause and subsequent development of digital dermatitis are complex, and the experimental model gives us a better understanding of the important role the bacteria play in the process," Gomez Rivas, who identified treponemes as a primary culprit in 2011, said.

Field tests have shown that the botanical hoof bath also helps prevent chronic lesions, which is vitally important for controlling the disease. While acute active lesions can cause pain and lameness, they can be readily treated with topical antibiotics.

"Even after topical treatment of these active lesions, treponemes still reside deep in the skin," Dopfer said. "This can cause chronic lesions, which have thick skin and spread rapidly. They act as reservoirs of infection, and they are precursors to new, acute lesions."

Eventually, Dopfer hopes to see widespread adoption of an integrated prevention and control system — including detailed herd records — for digital dermatitis.

Volume:85 Issue:47

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