New grant to study dairy herd productivity, fertility

New multi-state, $3m USDA grant will fund project aimed at genomics of dairy cow fertility.

For years, dairy producers have been selectively breeding their herds to encourage milk production. New insights have confirmed, though, that such efforts to satisfy society's demand for dairy products are hindering the cow herd's ability to bear offspring.

A new multi-state, $3 million U.S. Department of Agriculture grant, with scientists from five veterinary colleges across the country, aims to investigate the issue.

According to an announcement from Cornell University, Scientists will identify 12,000 cows that represent different breeding protocols (heat detection and synchronization of ovulation programs), different U.S. geographic regions and different types of facilities. Phenotypes will be explored using traditional time intervals and conception results (conception rate, number of services per conception, time to first breeding/conception), with physiologic measures and intermediate events such as resumption of ovarian cyclicity, postpartum uterine health (retained placenta, metritis and endometritis) and early embryonic and fetal loss. In addition, DNA will be collected from every cow.

With this data, the research team will identify cows in two groups — the most and least fertile — and compare changes in the DNA and corresponding fertility traits using genomewide analysis, the announcement explained. Researchers will also identify significant molecular markers to be included in fertility DNA analysis kits.

"It is our central hypothesis that reproductive efficiency depends, to some extent, on biological factors that are influenced and modulated by genetic variation," said Dr. Rodrigo Bicalho, assistant professor of dairy production medicine at Cornell and a co-principal investigator with Dr. Robert Gilbert for the project at Cornell. "Because of this, we expect to find differences in the DNA for the most fertile cows as compared to the least fertile cows.

"With this data, we can develop a genetic test that can be used to predict fertility immediately after birth, eliminating our current reliance on the very time-consuming and costly process of selecting from registered and phenotypically beautiful animals with good pedigrees," he said. "Sometimes looks and lineage can be deceiving, but currently it takes years to confirm this."

The grant also funds the development and delivery of a comprehensive, research-based extension program that will share the best selection practices for bull studs and for on-farm use with the replacement heifers that will improve fertility and the overall productivity of dairy herds.

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