First metritis vaccines developed for dairy cows

First metritis vaccines developed for dairy cows

CORNELL University scientists have created the first vaccines for dairy cattle that can prevent metritis, one of the most common cattle diseases.

The uterine infection not only harms animals and farmers' profits but also drives more systemic antibiotic use on dairy farms than any other disease, Cornell said.

The new vaccines prevent metritis infection of the uterus from taking hold and reduce symptoms when it does — a prospect that could save the U.S. billions of dollars a year and help curb the growing epidemic of antibiotic resistance, the university said in its announcement. The research was published March 17 in the journal PLOS One.

Metritis develops after a cow gives birth, when bacteria take advantage of the open vagina and cervix to settle into the uterus. Infected cows suffer fever, pain, inflammation, lack of appetite, depression and reduced reproductive abilities. Metritis affects as many as 25% of the roughly 9 million dairy cows in the U.S., costing nearly $400 per case in lost productivity and treatment costs.

It is the number-one cause of systemic antibiotic use, which floods the whole body with antibiotics rather than just a specific region, said Dr. Rodrigo Bicalho, assistant professor of dairy production medicine with Cornell's College of Veterinary Medicine.

Three of the vaccines Bicalho's laboratory created lowered metritis incidence and lessened its symptoms in the cows that received them, showing promise for alternatives to antibiotics in addressing the disease.

"Our lab has been developing a vaccine for years now based on our research of this disease," Bicalho said. "We created multivalent vaccines — complex cocktails with several components we've identified as important to causing metritis."

Bicalho and his team tested five combinations of various ingredients and delivered three via subcutaneous injection and two intravaginally. All three subcutaneous vaccines were effective, significantly reducing the incidence of disease by up to 83%, the announcement said. Cows that were vaccinated with the subcutaneous vaccines had a lower incidence of postpartum fever and puerperal metritis, shorter disease periods and improved reproductive performance compared to those that did not receive the vaccines.

"The powerful protection these vaccines produced surprised us. We expected some protective effect, but nothing as strong as what we found," Bicalho said. "An effective vaccine against uterine diseases will have a significant positive impact on the dairy industry, limiting the use of antibiotics and decreasing economic losses due to these disorders. Our next step is to simplify the complex vaccines we created by identifying which components are the most important and removing the rest."

Bicalho's laboratory is working in collaboration with Merck Animal Health to move the vaccines toward U.S. Department of Agriculture licensing, after which they should be made available for use.

The research for the paper, "Subcutaneous Immunization with Inactivated Bacterial Components & Purified Protein of Escherichia coli, Fusobacterium necrophorum & Trueperella pyogenes Prevents Puerperal Metritis in Holstein Dairy Cows," was funded by Merck Animal Health.

Volume:86 Issue:16

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