Cascade of events leading to prion disease described

New experiments in mice enable researchers to evaluate disease progression and potential therapeutic interventions in vivo.

Prion diseases are deadly neurodegenerative disorders in people and animals that are characterized by misfolded forms of prion protein, but development of effective treatments has been hampered by a lack of good experimental models.

In a new study published in The American Journal of Pathology, researchers described the distinct stages of prion disease in the mouse retina and defined an experimental model to specifically test therapeutic approaches.

The study, done

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