APC notes biosafety of porcine plasma

APC has completed a series of experiments to determine the biosafety of spray-dried porcine plasma.

Recently, spray-dried porcine plasma has been implicated as a vector responsible for the introduction of porcine epidemic diarrhea virus (PEDV) into Canada. APC Inc., a significant spray-dried porcine plasma manufacturer, recently released a technical brief on the biosafety of spray-dried porcine plasma relative to PEDV.

APC noted that further scientific investigation indicates that environmental contamination is a more likely explanation.

APC has completed a series of experiments to determine the biosafety of spray-dried porcine plasma, and the results of some of these experiments reported herein indicate the following:

• PEDV does not survive spray-drying.

• Experimentally inoculated spray-dried plasma loses infectivity by seven days when stored at room temperature.

• Results from an APC-sponsored pig bioassay demonstrate that two retained samples from the lot of spray-dried porcine plasma investigated by the Canadian Food Inspection Agency (CFIA) and two other samples of polymerase chain reaction (PCR)-positive commercial spray-dried porcine plasma did not contain infective PEDV.

• Independent of APC research, the U.S. Food & Drug Administration acquired samples of the specific lot of spray-dried porcine plasma investigated by CFIA. Three of these samples, corresponding to the CFIA samples, were prepared and inoculated into 17- to 19-day-old piglets (five pigs per lot). All three samples were negative by bioassay. The FDA results were consistent with the results of the APC bioassays.

• Weaned pigs fed a diet with 5% PCR-positive commercial spray-dried porcine plasma for 14 days after weaning remained PEDV negative for the 21 day feeding period as determined by absence of serum antibodies against PEDV and by negative PCR analysis of fecal swabs and intestinal contents for PEDV.

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