Target MRSA with tailored chemistry

Targeting bacteria's use of vitamin B9 could prevent antibiotic resistance.

University of Connecticut (UConn) medicinal chemists have developed experimental antibiotics that kill methicillin-resistant Staphylococcus aureus (MRSA), a common and often deadly bacteria that causes skin, lung and heart infections.

The success is due to their strategy, which found a weakness and exploited it in a way that the bacteria should have trouble countering, the researchers reported in the Dec. 22 issue of Cell Chemical Biology.

Cases of MRSA are o

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