Study details how kinases confer resistance to macrolides

Discovery could lead to design of next-generation antibiotics.

Antibiotic resistance is a growing global health threat, so it is critical that researchers develop new antibiotics informed by knowledge of how pathogens become resistant to these medications.

To help on this front, in a new paper published in the journal Structure, researchers from McGill University in Quebec presented in atomic detail how specific bacterial enzymes, known as kinases, confer resistance to macrolide antibiotics, a widely used class of antibiotics in human an

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