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ARS helps launch 'i5k' to sequence insect genomes

The "i5k Initiative" aims to sequence and analyze the genomes of at least 5,000 important insect species.

Nearly 75% of all animal species are insects and other arthropods. Many profoundly affect people and the Earth's ecology.

Some insects pollinate a third of our food crops. Others destroy one-fifth of the world's total crop production annually.

Given the importance of arthropods, the U.S. Department of Agriculture's Agricultural Research Service (ARS) helped organize the "i5k Initiative." The goal is to sequence and analyze the genomes of at least 5,000 arthropod species that are important to both agriculture and biological research.

Resistance to pesticides used to control arthropod damage to livestock and crops is an evolving problem, ARS said. Solutions to such challenges lie in the genomes of pests and their hosts. "This is where we will find new ways to manage them," explained Kevin Hackett, ARS national program leader for entomology and i5k co-founder and co-chair.

Arthropods' massive numbers mean there are fewer scientists and resources available to work on each species. The i5k project virtually connects scientists from around the world to leverage resources and foster discussions.

The i5k genomics are leading to advances that dovetail with today's headlines. For instance, a spike in ticks this summer made news, and ticks were also among i5k's successes.

When ARS insect physiologist Felix Guerrero and his team sequenced the cattle tick genome, they identified genes now being used to develop a vaccine against cattle fever ticks. This vaccine may protect cattle from several fatal tickborne diseases and eventually fight ticks that spread Lyme disease to people.

Parallel with the i5k initiative, ARS's National Agricultural Library (NAL) built the "i5k [email protected]," which provides an online "tool shed" in which researchers work cooperatively to sequence genomes. It ensures wide access to data in a place that researchers see as neutral ground for collaboration, NAL project co-lead Christopher Childers explained.

The i5k [email protected] works: In April 2017, more than 60 scientists from seven countries and institutions, including ARS, collectively published an analysis of 14,220 genes in the bed bug's genome. This research is a foundation for new bed bug control methods.

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